Tissue Tregs in Annual Reviews of Immunology

Our latest review is out, a comprehensive synthesis of tissue Tregs. It has been a decade since Annual Reviews of Immunology last reviewed tissue Tregs, and there have been enormous advances and conceptual leaps forward in the field.

Tissue Tregs have now been found in essentially all tissues, and have broadly conserved properties of enhancing repair and rejuvenation as well as controlling local inflammation. While the impact on tissues differ, molecular mediators are largely shared across tissues. The molecular cues that induce the tissue Treg phenotype are only partially understood, but key external signals from the tissue environment seem to be important in upregulating a core transcription factor set, which remodels the epigenetic and transcriptional landscape.

The cellular kinetics are not fully understood, however the majority of evidence using parabiosis, TCR retrogenics, cell transfers and fate-mappers suggest that the majority of tissue Tregs are pan-tissue, multi-tissue or tissue-cycling in their behaviour during homeostasis.

We also cover the increasingly promising attempts to exploit the properties of tissue Tregs in the clinic, and outline the key open questions for the field. 

Read the full article here.